Welcome to the Lumata research group website! We are a biomedical physics research team in the Department of Physics at the University of Texas at Dallas. Our lab's main research is focused on hyperpolarized magnetic resonance: instrumentation, physics, optimization methods and biomedical applications (specifically, aberrant cellular metabolism in cancer). Hyperpolarization, technically dynamic nuclear polarization (DNP), is a physics technique wherein we create a high degree of non-Boltzmann distribution of insensitive nuclear spins at low temperature and high magnetic field via microwave irradiation of free electrons. Our goal is to get the highest enhanced nuclear polarization possible for insensitive nuclear spins such as 13C, 15N, 89Y, 107,109Ag etc. by optimizing the physical parameters at cryogenic conditions (close to 1K). We then utilize a fast dissolution device that converts the frozen hyperpolarized samples at cryogenic conditions into hyperpolarized liquids at physiologically tolerable temperatures. What this means is that the NMR and MRI signals of reporter molecules (NMR/MRI molecular probes that can detect pH, metabolism, and other important biological activities) are enhanced by 10,000-100,000-fold! We aim to explore and investigate new hyperpolarized NMR and MRI biosensors to improve medical diagnostics. Join us!
-Ph.D. student (2013-present), UTD
-B.S. Physics & Mathematics (2012), Midwestern State University, TX
-Member, American Physical Society (APS)
Research interest: Hyperpolarization, NMR, chemical physics
lab phone number: 972-883-2877 (NB 1.131)
Peter Niedbalski, Ph.D. student (2013-2017). current position: Postdoctoral researcher at Cincinnati Children's Hospital Medical Center.
Andhika Kiswandhi, postdoctoral researcher (2015-2017). Current position: JSPS Fellow, Kyoto University, Japan.
Sarah Ferguson, M.S. Physics, Lumata lab member (2014-2016)
Armin Khamoshi, Physics, undergraduate student (2014-2016).
Tran Thang, Physics, undergraduate student (2015-2017).
Eduardo Cervantes, Physics, undergraduate student (2015-2017).
Jayanth Harkara, Mechanical Engineering, undergraduate student (2016).
Michelle Tran, Biology, undergraduate student (2016).
Canice Lei Dancel, Biology, undergraduate student (2016).
Artem Bolshakov, Physics, undergraduate student (2016).
Kylie Tacker, B.S. Geophysics, Lumata Lab member (Fall 2014
-current position: undergraduate researcher at Dr. Anvar Zhakidov's lab (UT Dallas).
Mudrekh Goderya, B.S. Physics and Computer Science, Lumata lab member (Fall 2014)
-current position: Software developer, PetroCloud, Irving, TX
Anagha Krishnan, Texas Academy of Mathematics and Science, High School UTD Nanoexplorer (Summer 2015)
Aayush Goyal, Texas Academy of Mathematics and Science, High School UTD Nanoexplorer (Summer 2015)
Anisha Oommen, Stanford University Online High School, UTD Nanoexplorer (Summer 2015)
U.S. Department of Defense (DoD) - Prostate Cancer Research Program (PCRP)
Exploration-Hypothesis Development Grant Award
Principal Investigator: Lloyd Lumata
Hyperpolarized 15N Magnetic Resonance Imaging of Prostate Cancer
Total funding: $114,750.00 (October 2015-October 2016), Award No. W81XWH-14-1-0048
We are looking for highly motivated members (graduate students) for the Lumata research group. Projects include the development of dynamic nuclear polarization (DNP)/hyperpolarization instrumentation for biomedical NMR spectroscopy and imaging, optimization of DNP signals, ESR of free radical polarizing agents (in collaboration with the National High Magnetic Field Laboratory in Tallahassee, FL), in vitro hyperpolarized NMR spectroscopy of cancer cells, and in vivo hyperpolarized 15N MRI of prostate cancer (in collaboration with Advanced Imaging Research Center, UT Southwestern Medical Center). Please inquire from the PI (email: email@example.com) for more details.
UT Dallas Graduate Physics Program from American Institute of Physics (AIP) catalog